Toxicant-Receptor Interactions: Modulations of signal transduction and gene expression

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Michael Denison, William Helferich
CRC Press, 1998 M08 10 - 243 páginas
Many of the toxic effects elicited by xenobiotics can be explained at the molecular level by their interaction with receptors or by disruption or interference with receptor-mediated signal transduction pathways. This volume describes molecular approaches and reviews of current research. It provides reviews of numerous research areas which are direc
 

Contenido

The Ah Receptor Signal Transduction Pathway
3
The Peroxisome ProliferatorActivated Receptor
35
Effects of Xenobiotics on Hormone Receptors
53
Interactions Between Environmental Xenobiotics and Estrogen ReceptorMediated Responses
69
BarbiturateInducible Gene Expression
103
AntioxidantInducible Detoxifying Enzyme Gene Expression
133
Mechanism of Heavy MetalInducible Gene Transcription
143
Modulation of Protein Kinases by Xenobiotics
161
Cellular Calcium Regulation and Signaling
185
Approaches for the Identification of XenobioticInducible Genes
217
Index
237
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Michael Denison, William Helferich

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