Anabolic Treatments for OsteoporosisCRC Press, 1997 M10 20 - 288 páginas Osteoporosis, a growing epidemic among women in North America, Europe, and Japan, is a painful, costly disease that has presented a treatment challenge to healthcare professionals. Until recently, therapies have focused on agents that slow bone resorption, and have had only limited success at increasing bone mass. However, exciting new developments are on the verge of changing the treatment of this debilitating disorder. Two anabolic agents, the parathyroid hormone (PTH) and the fluoride ion, show tremendous promise as tools for building and retaining bone - with no adverse side effects. Anabolic Treatments for Osteoporosis is a comprehensive account of the latest studies that have been carried out on these two agents, and a thorough assessment of their prospects as osteoporosis therapeutics. This unique book combines basic science and up-to-date clinical data to present a complete picture of this breakthrough in the treatment of a globally significant health issue. |
Contenido
Therapeutic Objectives Targets Problems | 13 |
On Differences in Vertebral Body and LongBone | 20 |
Chapter 2 | 21 |
Glossary | 28 |
Chapter 3 | 59 |
Chapter 4 | 83 |
Chapter 5 | 109 |
Chapter 9 | 131 |
Chapter 6 | 151 |
Chapter 7 | 175 |
Its Therapeutic Use for Established | 207 |
256 | |
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Términos y frases comunes
activity adenylyl cyclase anabolic agents anabolic effects analogs animal models antiresorptive agents Baylink biochemical biomechanical bisphosphonates bone cells bone loss bone mass bone quality bone remodeling bone resorption bone strength bone turnover Calcif calcitonin calcitriol cancellous bone Clin clinical cortical bone cyclic doses effect on bone effects of fluoride effects of PTH Endocrinology estrogen fluoride on bone fluoride therapy fluoride treatment fracture rate gene growth factor histomorphometric Hodsman hPTH human parathyroid hormone IGF-I IGFBPs IGFs increase bone increase in bone injections intermittent kinase lumbar mechanostat Metab metabolism Mosekilde normal osteoblasts osteocalcin osteogenic osteopenia osteoporotic patients ovariectomized rats OVX rats parathyroid hormone parathyroid hormone-related protein peptide phosphatase postmenopausal osteoporosis proliferation prostaglandin protein PTH therapy PTH treatment PTHrP receptor response rhIGF-I serum fluoride side effects skeletal skeleton sodium fluoride structure studies subcutaneous Suppl therapeutic Tissue Int trabecular bone treatment of osteoporosis vertebral body vitro vivo Wronski
Referencias a este libro
The Parathyroids: Basic and Clinical Concepts John P. Bilezikian,Robert Marcus,Michael A. Levine Vista previa limitada - 2001 |