Endorphins and Opiate Antagonists in Psychiatric Research: Clinical Implications

Portada
Springer Science & Business Media, 2012 M12 6 - 510 páginas
The discovery of new molecules that function in neuronal communication can be viewed as a progression of steps beginning with the identification of the molecular structure, moving to the understanding of the mecha nisms mediating the synaptic action, and to the appraisal of the involve ment of the new molecules in various neuronal mechanisms, and finally reaching the evaluation of this molecule's role in brain function and the consequences that are triggered by its abnormalities. Enkephalins have followed such a pattern, and the present publication expresses the salient points of the last two phases in this succession. Enkephalins were discovered in December 1975; in addition to pain threshold regulation, their participation in other brain functions was soon ascertained. Perhaps, there are multiple recognition sites for multiple molecular forms of endogenous enkephalins; similarly to other transmitter recognition sites, these are coupled with ionic and nucleotide amplifying systems; thus, when activated, they can modify membrane funtion and ionic permeability of membranes. The present publication probes the current status of our knowledge concerning the consequences related to abnormalities in enkephalin storage, release, and synthesis. However, since our basic understanding of enkephalins is incomplete, the views reported should be considered to be in a state of flux.
 

Comentarios de la gente - Escribir un comentario

No encontramos ningún comentario en los lugares habituales.

Contenido

INTRODUCTION
1
CHAPTER
4
CHAPTER
15
CHAPTER 2
41
CHAPTER 3
61
Possible Roles of Prostaglandins in Mediating Opioid Actions
75
CHAPTER 5
89
CHAPTER 6
99
CHAPTER 13
257
CHAPTER 14
271
CHAPTER 15
291
CHAPTER 16
305
CHAPTER 18
333
CHAPTER 19
347
CHAPTER 21
375
CHAPTER 22
399

CHAPTER 7
127
CHAPTER 8
161
Opiate Receptors and Opiate Antagonists in Psychiatric
179
CHAPTER 10
213
CHAPTER 11
231
CHAPTER 12
245
CHAPTER 23
407
CHAPTER 24
427
CHAPTER 25
439
CHAPTER 26
451
CHAPTER 27
459
Derechos de autor

Otras ediciones - Ver todas

Términos y frases comunes

Información bibliográfica