Endorphins and Opiate Antagonists in Psychiatric Research: Clinical ImplicationsSpringer Science & Business Media, 2012 M12 6 - 510 páginas The discovery of new molecules that function in neuronal communication can be viewed as a progression of steps beginning with the identification of the molecular structure, moving to the understanding of the mecha nisms mediating the synaptic action, and to the appraisal of the involve ment of the new molecules in various neuronal mechanisms, and finally reaching the evaluation of this molecule's role in brain function and the consequences that are triggered by its abnormalities. Enkephalins have followed such a pattern, and the present publication expresses the salient points of the last two phases in this succession. Enkephalins were discovered in December 1975; in addition to pain threshold regulation, their participation in other brain functions was soon ascertained. Perhaps, there are multiple recognition sites for multiple molecular forms of endogenous enkephalins; similarly to other transmitter recognition sites, these are coupled with ionic and nucleotide amplifying systems; thus, when activated, they can modify membrane funtion and ionic permeability of membranes. The present publication probes the current status of our knowledge concerning the consequences related to abnormalities in enkephalin storage, release, and synthesis. However, since our basic understanding of enkephalins is incomplete, the views reported should be considered to be in a state of flux. |
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... Hormone Research Laboratory , University of California , San Francisco , California L. H. LINDSTRÖM Psychiatric Research Center , Uppsala , Sweden • ANTHONY S. LIOTTA Division of Endocrinology , Department of Medicine , Mount Sinai ...
... Hormone Research Laboratory , University of California , San Francisco , California L. H. LINDSTRÖM Psychiatric Research Center , Uppsala , Sweden • ANTHONY S. LIOTTA Division of Endocrinology , Department of Medicine , Mount Sinai ...
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... hormone levels , Lancet 2 : 320 . Jasinski , D. R. , Martin , W. R. , and Haertzen , C. A. , 1967 , The human pharmacology and abuse potential of N - allyl - noroxymorphone ( naloxone ) , J. Pharmacol . Exp . Ther . 157 : 2 . Jørgensen ...
... hormone levels , Lancet 2 : 320 . Jasinski , D. R. , Martin , W. R. , and Haertzen , C. A. , 1967 , The human pharmacology and abuse potential of N - allyl - noroxymorphone ( naloxone ) , J. Pharmacol . Exp . Ther . 157 : 2 . Jørgensen ...
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... hormone study . The reason for this receptor postulate was the high degree of struc- tural and steric specificity that characterizes the action of opiates . Thus , for a large number of morphine - like analgesics studied it is only the ...
... hormone study . The reason for this receptor postulate was the high degree of struc- tural and steric specificity that characterizes the action of opiates . Thus , for a large number of morphine - like analgesics studied it is only the ...
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... hormone first isolated from the pituitary gland by Li ( 1964 ) . This finding led rapidly to the uncovering of three longer peptides with opioid activity , all representing sequences present in ß - LPH , i.e. , a - endorphin ( B - LPH61 ...
... hormone first isolated from the pituitary gland by Li ( 1964 ) . This finding led rapidly to the uncovering of three longer peptides with opioid activity , all representing sequences present in ß - LPH , i.e. , a - endorphin ( B - LPH61 ...
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... hormone , prolactin , and ACTH , and inhibit the release of luteinizing hormone , follicle - stimulating hormone , and thyrotropin . All these effects are reversible by naloxone and this is , in fact , one of the rare instances where ...
... hormone , prolactin , and ACTH , and inhibit the release of luteinizing hormone , follicle - stimulating hormone , and thyrotropin . All these effects are reversible by naloxone and this is , in fact , one of the rare instances where ...
Contenido
1 | |
4 | |
9 | |
15 | |
CHAPTER 2 | 41 |
CHAPTER 3 | 61 |
Possible Roles of Prostaglandins in Mediating Opioid Actions | 75 |
CHAPTER 5 | 89 |
CHAPTER 13 | 257 |
CHAPTER 14 | 271 |
CHAPTER 15 | 291 |
CHAPTER 16 | 305 |
CHAPTER 18 | 333 |
CHAPTER 19 | 347 |
CHAPTER 21 | 375 |
Enkephalin Naloxone and DESTYR¹yEndorphin | 399 |
CHAPTER 6 | 99 |
CHAPTER 7 | 127 |
CHAPTER 8 | 161 |
CHAPTER 9 | 179 |
CHAPTER 10 | 213 |
CHAPTER 11 | 231 |
CHAPTER 12 | 245 |
CHAPTER 23 | 407 |
CHAPTER 24 | 427 |
CHAPTER 25 | 439 |
CHAPTER 26 | 451 |
CHAPTER 27 | 459 |
Index | 477 |
Otras ediciones - Ver todas
Endorphins and Opiate Antagonists in Psychiatric Research: Clinical Implications Nandkumar S. Shah,Alexander G. Donald Sin vista previa disponible - 2012 |
Términos y frases comunes
Acad acid ACTH action activity administration Akil analgesia analgesic analogs antipsychotic assay B-LPH Barchas behavioral effects Biochem Bloom Brain Res Bunney cerebrospinal fluid chronic clinical concentrations decrease depressed patients dialysate disorders dopamine doses double-blind drugs DTYE Effects of naloxone electrical stimulation endogenous opiates endogenous opioid peptides endorphin levels endorphins enkephalin fraction Goldstein Guillemin hallucinations haloperidol hemodialyses Höllt human hypothalamus immunoreactivity increase infusion inhibition injection Kastin Kline Kosterlitz Lancet ligands lipotropin manic Met-enkephalin methadone morphine naloxone naltrexone narcotic antagonist Natl Nature London neuroleptic neurons Neurosci normal nucleus opiate agonists opiate antagonist opiate peptides opiate receptors opioid peptides pain periaqueductal gray Pert Pharmacol pharmacological placebo plasma potent Proc prolactin Psychiatry psychotic rat brain receptor binding release reported response role schizo schizophrenic schizophrenic patients Science serum Snyder spinal ẞ-endorphin Stereospecific striatum studies suggest symptoms syndrome Terenius tissue treatment vitro Wahlström