Endorphins and Opiate Antagonists in Psychiatric Research: Clinical ImplicationsSpringer Science & Business Media, 2012 M12 6 - 510 páginas The discovery of new molecules that function in neuronal communication can be viewed as a progression of steps beginning with the identification of the molecular structure, moving to the understanding of the mecha nisms mediating the synaptic action, and to the appraisal of the involve ment of the new molecules in various neuronal mechanisms, and finally reaching the evaluation of this molecule's role in brain function and the consequences that are triggered by its abnormalities. Enkephalins have followed such a pattern, and the present publication expresses the salient points of the last two phases in this succession. Enkephalins were discovered in December 1975; in addition to pain threshold regulation, their participation in other brain functions was soon ascertained. Perhaps, there are multiple recognition sites for multiple molecular forms of endogenous enkephalins; similarly to other transmitter recognition sites, these are coupled with ionic and nucleotide amplifying systems; thus, when activated, they can modify membrane funtion and ionic permeability of membranes. The present publication probes the current status of our knowledge concerning the consequences related to abnormalities in enkephalin storage, release, and synthesis. However, since our basic understanding of enkephalins is incomplete, the views reported should be considered to be in a state of flux. |
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Página 4
... human catatonia , i.e. , ẞ - endorphin - induced muscular rigidity in the rat . This model has been used in experimental procedures for the production of catatonia by intracerebroventricular injection of ß - endorphin ( Bloom et al ...
... human catatonia , i.e. , ẞ - endorphin - induced muscular rigidity in the rat . This model has been used in experimental procedures for the production of catatonia by intracerebroventricular injection of ß - endorphin ( Bloom et al ...
Página 11
... human pituitary glands , Biochem . Biophys . Res . Commun . 72 : 1542 . Lindström , L. H. , Widerlöv , E. , Gunne , L.-M. , Wahlström , A. , and Terenius , L. , 1978 , Endorphins in human cerebrospinal fluid : Clinical correlations in ...
... human pituitary glands , Biochem . Biophys . Res . Commun . 72 : 1542 . Lindström , L. H. , Widerlöv , E. , Gunne , L.-M. , Wahlström , A. , and Terenius , L. , 1978 , Endorphins in human cerebrospinal fluid : Clinical correlations in ...
Página 28
... human plasma or rat brain homogenates ( Hambrook et al . , 1976 ) . Substitutions at position 5 further increase stability , sug- gesting that carboxypeptidases are also involved in enkephalin breakdown ( Bajusz et al . , 1976 ) . A ...
... human plasma or rat brain homogenates ( Hambrook et al . , 1976 ) . Substitutions at position 5 further increase stability , sug- gesting that carboxypeptidases are also involved in enkephalin breakdown ( Bajusz et al . , 1976 ) . A ...
Página 32
... human , Pain 2 : 161 . Akil , H. , Mayer , D. J. , and Liebeskind , J. C. , 1976 , Antagonism of stimulation - produced analgesia by naloxone , a narcotic antagonist , Science 191 : 961 . Akil , H. , Richardson , D. E. , Hughes , J ...
... human , Pain 2 : 161 . Akil , H. , Mayer , D. J. , and Liebeskind , J. C. , 1976 , Antagonism of stimulation - produced analgesia by naloxone , a narcotic antagonist , Science 191 : 961 . Akil , H. , Richardson , D. E. , Hughes , J ...
Página 34
... humans , Nature ( London ) 263 : 783 . Florez , J. , and Mediavilla , A. , 1977 , Respiratory and cardiovascular effect of Met - enkephalin applied to the ventral surface of the brain stem . Brain ... human plasma and rat 34 JACOB M. HILLER.
... humans , Nature ( London ) 263 : 783 . Florez , J. , and Mediavilla , A. , 1977 , Respiratory and cardiovascular effect of Met - enkephalin applied to the ventral surface of the brain stem . Brain ... human plasma and rat 34 JACOB M. HILLER.
Contenido
1 | |
4 | |
9 | |
15 | |
CHAPTER 2 | 41 |
CHAPTER 3 | 61 |
Possible Roles of Prostaglandins in Mediating Opioid Actions | 75 |
CHAPTER 5 | 89 |
CHAPTER 13 | 257 |
CHAPTER 14 | 271 |
CHAPTER 15 | 291 |
CHAPTER 16 | 305 |
CHAPTER 18 | 333 |
CHAPTER 19 | 347 |
CHAPTER 21 | 375 |
Enkephalin Naloxone and DESTYR¹yEndorphin | 399 |
CHAPTER 6 | 99 |
CHAPTER 7 | 127 |
CHAPTER 8 | 161 |
CHAPTER 9 | 179 |
CHAPTER 10 | 213 |
CHAPTER 11 | 231 |
CHAPTER 12 | 245 |
CHAPTER 23 | 407 |
CHAPTER 24 | 427 |
CHAPTER 25 | 439 |
CHAPTER 26 | 451 |
CHAPTER 27 | 459 |
Index | 477 |
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Endorphins and Opiate Antagonists in Psychiatric Research: Clinical Implications Nandkumar S. Shah,Alexander G. Donald Sin vista previa disponible - 2012 |
Términos y frases comunes
Acad acid ACTH action activity administration Akil analgesia analgesic analogs antipsychotic assay B-LPH Barchas behavioral effects Biochem Bloom Brain Res Bunney cerebrospinal fluid chronic clinical concentrations decrease depressed patients dialysate disorders dopamine doses double-blind drugs DTYE Effects of naloxone electrical stimulation endogenous opiates endogenous opioid peptides endorphin levels endorphins enkephalin fraction Goldstein Guillemin hallucinations haloperidol hemodialyses Höllt human hypothalamus immunoreactivity increase infusion inhibition injection Kastin Kline Kosterlitz Lancet ligands lipotropin manic Met-enkephalin methadone morphine naloxone naltrexone narcotic antagonist Natl Nature London neuroleptic neurons Neurosci normal nucleus opiate agonists opiate antagonist opiate peptides opiate receptors opioid peptides pain periaqueductal gray Pert Pharmacol pharmacological placebo plasma potent Proc prolactin Psychiatry psychotic rat brain receptor binding release reported response role schizo schizophrenic schizophrenic patients Science serum Snyder spinal ẞ-endorphin Stereospecific striatum studies suggest symptoms syndrome Terenius tissue treatment vitro Wahlström