Endorphins and Opiate Antagonists in Psychiatric Research: Clinical ImplicationsSpringer Science & Business Media, 2012 M12 6 - 510 páginas The discovery of new molecules that function in neuronal communication can be viewed as a progression of steps beginning with the identification of the molecular structure, moving to the understanding of the mecha nisms mediating the synaptic action, and to the appraisal of the involve ment of the new molecules in various neuronal mechanisms, and finally reaching the evaluation of this molecule's role in brain function and the consequences that are triggered by its abnormalities. Enkephalins have followed such a pattern, and the present publication expresses the salient points of the last two phases in this succession. Enkephalins were discovered in December 1975; in addition to pain threshold regulation, their participation in other brain functions was soon ascertained. Perhaps, there are multiple recognition sites for multiple molecular forms of endogenous enkephalins; similarly to other transmitter recognition sites, these are coupled with ionic and nucleotide amplifying systems; thus, when activated, they can modify membrane funtion and ionic permeability of membranes. The present publication probes the current status of our knowledge concerning the consequences related to abnormalities in enkephalin storage, release, and synthesis. However, since our basic understanding of enkephalins is incomplete, the views reported should be considered to be in a state of flux. |
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Resultados 1-5 de 47
Página 8
... infusion of human ẞ - endorphin alleviated the depressive symp- toms , thereby establishing endorphin deficiency . Other studies reported the presence of increased concentrations of uncharacterized endorphins in the CSF of manic ...
... infusion of human ẞ - endorphin alleviated the depressive symp- toms , thereby establishing endorphin deficiency . Other studies reported the presence of increased concentrations of uncharacterized endorphins in the CSF of manic ...
Página 10
... infusion causes behavioral change in psychiatric inpatients , Arch . Gen. Psychiatry 37 : 642 . Gramsch , C. H. , Höllt , V. , Mehraein , P. , Pasi , A. , and Herz , A. , 1978 , Regional distribution of endorphin in human brain and ...
... infusion causes behavioral change in psychiatric inpatients , Arch . Gen. Psychiatry 37 : 642 . Gramsch , C. H. , Höllt , V. , Mehraein , P. , Pasi , A. , and Herz , A. , 1978 , Regional distribution of endorphin in human brain and ...
Página 26
... infusion into the periaqueductal gray - fourth ventricular spaces of rat brain ( Wei and Loh , 1976 ) . The endorphins can substitute for morphine in the suppression of withdrawal symptoms in morphine - dependent animals ( Mello and ...
... infusion into the periaqueductal gray - fourth ventricular spaces of rat brain ( Wei and Loh , 1976 ) . The endorphins can substitute for morphine in the suppression of withdrawal symptoms in morphine - dependent animals ( Mello and ...
Página 28
... infusion of 3H - labeled amino acids , Yang et al . ( 1978 ) isolated 3H - labeled enkephalin . 3H - labeled enkephalin was also isolated from guinea pig ileum myenteric plexus and from slices of striatum from guinea pig brain ...
... infusion of 3H - labeled amino acids , Yang et al . ( 1978 ) isolated 3H - labeled enkephalin . 3H - labeled enkephalin was also isolated from guinea pig ileum myenteric plexus and from slices of striatum from guinea pig brain ...
Página 34
... infusion causes behavioral change in psychiatric inpatients , Arch . Gen. Psychiatry 37 : 642 . Gilbert , P. E. , and Martin , W. R. , 1976 , The effects of morphine- and nalorphine - like drugs in the nondependent , morphine ...
... infusion causes behavioral change in psychiatric inpatients , Arch . Gen. Psychiatry 37 : 642 . Gilbert , P. E. , and Martin , W. R. , 1976 , The effects of morphine- and nalorphine - like drugs in the nondependent , morphine ...
Contenido
1 | |
4 | |
9 | |
15 | |
CHAPTER 2 | 41 |
CHAPTER 3 | 61 |
Possible Roles of Prostaglandins in Mediating Opioid Actions | 75 |
CHAPTER 5 | 89 |
CHAPTER 13 | 257 |
CHAPTER 14 | 271 |
CHAPTER 15 | 291 |
CHAPTER 16 | 305 |
CHAPTER 18 | 333 |
CHAPTER 19 | 347 |
CHAPTER 21 | 375 |
Enkephalin Naloxone and DESTYR¹yEndorphin | 399 |
CHAPTER 6 | 99 |
CHAPTER 7 | 127 |
CHAPTER 8 | 161 |
CHAPTER 9 | 179 |
CHAPTER 10 | 213 |
CHAPTER 11 | 231 |
CHAPTER 12 | 245 |
CHAPTER 23 | 407 |
CHAPTER 24 | 427 |
CHAPTER 25 | 439 |
CHAPTER 26 | 451 |
CHAPTER 27 | 459 |
Index | 477 |
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Endorphins and Opiate Antagonists in Psychiatric Research: Clinical Implications Nandkumar S. Shah,Alexander G. Donald Sin vista previa disponible - 2012 |
Términos y frases comunes
Acad acid ACTH action activity administration Akil analgesia analgesic analogs antipsychotic assay B-LPH Barchas behavioral effects Biochem Bloom Brain Res Bunney cerebrospinal fluid chronic clinical concentrations decrease depressed patients dialysate disorders dopamine doses double-blind drugs DTYE Effects of naloxone electrical stimulation endogenous opiates endogenous opioid peptides endorphin levels endorphins enkephalin fraction Goldstein Guillemin hallucinations haloperidol hemodialyses Höllt human hypothalamus immunoreactivity increase infusion inhibition injection Kastin Kline Kosterlitz Lancet ligands lipotropin manic Met-enkephalin methadone morphine naloxone naltrexone narcotic antagonist Natl Nature London neuroleptic neurons Neurosci normal nucleus opiate agonists opiate antagonist opiate peptides opiate receptors opioid peptides pain periaqueductal gray Pert Pharmacol pharmacological placebo plasma potent Proc prolactin Psychiatry psychotic rat brain receptor binding release reported response role schizo schizophrenic schizophrenic patients Science serum Snyder spinal ẞ-endorphin Stereospecific striatum studies suggest symptoms syndrome Terenius tissue treatment vitro Wahlström