Endorphins and Opiate Antagonists in Psychiatric Research: Clinical ImplicationsSpringer Science & Business Media, 2012 M12 6 - 510 páginas The discovery of new molecules that function in neuronal communication can be viewed as a progression of steps beginning with the identification of the molecular structure, moving to the understanding of the mecha nisms mediating the synaptic action, and to the appraisal of the involve ment of the new molecules in various neuronal mechanisms, and finally reaching the evaluation of this molecule's role in brain function and the consequences that are triggered by its abnormalities. Enkephalins have followed such a pattern, and the present publication expresses the salient points of the last two phases in this succession. Enkephalins were discovered in December 1975; in addition to pain threshold regulation, their participation in other brain functions was soon ascertained. Perhaps, there are multiple recognition sites for multiple molecular forms of endogenous enkephalins; similarly to other transmitter recognition sites, these are coupled with ionic and nucleotide amplifying systems; thus, when activated, they can modify membrane funtion and ionic permeability of membranes. The present publication probes the current status of our knowledge concerning the consequences related to abnormalities in enkephalin storage, release, and synthesis. However, since our basic understanding of enkephalins is incomplete, the views reported should be considered to be in a state of flux. |
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Resultados 1-5 de 89
Página 19
... inhibited and antagonist binding is aug- mented . This finding arose from a discrepancy between two laboratories in their reported results . Simon et al . ( 1973 ) reported that sodium inhibited the binding of [ 3H ] etorphine , while ...
... inhibited and antagonist binding is aug- mented . This finding arose from a discrepancy between two laboratories in their reported results . Simon et al . ( 1973 ) reported that sodium inhibited the binding of [ 3H ] etorphine , while ...
Página 24
... inhibit electrically induced contractions , the specificity of the inhibition can be confirmed by its reversibility by narcotic antagonists . Both methods suffer from the disadvantage of not distinguishing between different active ...
... inhibit electrically induced contractions , the specificity of the inhibition can be confirmed by its reversibility by narcotic antagonists . Both methods suffer from the disadvantage of not distinguishing between different active ...
Página 25
... inhibition of ax- onal transport with colchicine have permitted the visualization of enke- phalin - containing cell bodies . It is estimated there may be 20 or more separate groups of enkephalin - containing cells in the brain . The ...
... inhibition of ax- onal transport with colchicine have permitted the visualization of enke- phalin - containing cell bodies . It is estimated there may be 20 or more separate groups of enkephalin - containing cells in the brain . The ...
Página 27
... inhibition of electrical activity . This observation is seen in most brain regions . The exceptions are the Renshaw ... inhibit the release of luteinizing hormone , follicle - stimulating hormone , and thyrotropin . All these effects are ...
... inhibition of electrical activity . This observation is seen in most brain regions . The exceptions are the Renshaw ... inhibit the release of luteinizing hormone , follicle - stimulating hormone , and thyrotropin . All these effects are ...
Página 29
... inhibit the release of various neurotransmitters ( Taube et al . , 1976 ; Loh et al . , 1976 ; Jhamandas et al . , 1977 ) , along with the demonstration that opiate receptors can have a presynaptic location , has given rise to the ...
... inhibit the release of various neurotransmitters ( Taube et al . , 1976 ; Loh et al . , 1976 ; Jhamandas et al . , 1977 ) , along with the demonstration that opiate receptors can have a presynaptic location , has given rise to the ...
Contenido
1 | |
4 | |
9 | |
15 | |
CHAPTER 2 | 41 |
CHAPTER 3 | 61 |
Possible Roles of Prostaglandins in Mediating Opioid Actions | 75 |
CHAPTER 5 | 89 |
CHAPTER 13 | 257 |
CHAPTER 14 | 271 |
CHAPTER 15 | 291 |
CHAPTER 16 | 305 |
CHAPTER 18 | 333 |
CHAPTER 19 | 347 |
CHAPTER 21 | 375 |
Enkephalin Naloxone and DESTYR¹yEndorphin | 399 |
CHAPTER 6 | 99 |
CHAPTER 7 | 127 |
CHAPTER 8 | 161 |
CHAPTER 9 | 179 |
CHAPTER 10 | 213 |
CHAPTER 11 | 231 |
CHAPTER 12 | 245 |
CHAPTER 23 | 407 |
CHAPTER 24 | 427 |
CHAPTER 25 | 439 |
CHAPTER 26 | 451 |
CHAPTER 27 | 459 |
Index | 477 |
Otras ediciones - Ver todas
Endorphins and Opiate Antagonists in Psychiatric Research: Clinical Implications Nandkumar S. Shah,Alexander G. Donald Sin vista previa disponible - 2012 |
Términos y frases comunes
Acad acid ACTH action activity administration Akil analgesia analgesic analogs antipsychotic assay B-LPH Barchas behavioral effects Biochem Bloom Brain Res Bunney cerebrospinal fluid chronic clinical concentrations decrease depressed patients dialysate disorders dopamine doses double-blind drugs DTYE Effects of naloxone electrical stimulation endogenous opiates endogenous opioid peptides endorphin levels endorphins enkephalin fraction Goldstein Guillemin hallucinations haloperidol hemodialyses Höllt human hypothalamus immunoreactivity increase infusion inhibition injection Kastin Kline Kosterlitz Lancet ligands lipotropin manic Met-enkephalin methadone morphine naloxone naltrexone narcotic antagonist Natl Nature London neuroleptic neurons Neurosci normal nucleus opiate agonists opiate antagonist opiate peptides opiate receptors opioid peptides pain periaqueductal gray Pert Pharmacol pharmacological placebo plasma potent Proc prolactin Psychiatry psychotic rat brain receptor binding release reported response role schizo schizophrenic schizophrenic patients Science serum Snyder spinal ẞ-endorphin Stereospecific striatum studies suggest symptoms syndrome Terenius tissue treatment vitro Wahlström