Endorphins and Opiate Antagonists in Psychiatric Research: Clinical ImplicationsSpringer Science & Business Media, 2012 M12 6 - 510 páginas The discovery of new molecules that function in neuronal communication can be viewed as a progression of steps beginning with the identification of the molecular structure, moving to the understanding of the mecha nisms mediating the synaptic action, and to the appraisal of the involve ment of the new molecules in various neuronal mechanisms, and finally reaching the evaluation of this molecule's role in brain function and the consequences that are triggered by its abnormalities. Enkephalins have followed such a pattern, and the present publication expresses the salient points of the last two phases in this succession. Enkephalins were discovered in December 1975; in addition to pain threshold regulation, their participation in other brain functions was soon ascertained. Perhaps, there are multiple recognition sites for multiple molecular forms of endogenous enkephalins; similarly to other transmitter recognition sites, these are coupled with ionic and nucleotide amplifying systems; thus, when activated, they can modify membrane funtion and ionic permeability of membranes. The present publication probes the current status of our knowledge concerning the consequences related to abnormalities in enkephalin storage, release, and synthesis. However, since our basic understanding of enkephalins is incomplete, the views reported should be considered to be in a state of flux. |
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Resultados 1-5 de 61
Página 3
... psychotic patients , which led these investi- gators to suggest that increases in endorphin levels were perhaps ... psychosis . An exactly opposite view linking deficiencies of endorphins or endorphinlike compounds to schizophrenia ...
... psychotic patients , which led these investi- gators to suggest that increases in endorphin levels were perhaps ... psychosis . An exactly opposite view linking deficiencies of endorphins or endorphinlike compounds to schizophrenia ...
Página 4
... psychosis . Part of the supporting ev- idence for this hypothesis was obtained from an animal model of human catatonia , i.e. , ẞ - endorphin - induced muscular rigidity in the rat . This model has been used in experimental procedures ...
... psychosis . Part of the supporting ev- idence for this hypothesis was obtained from an animal model of human catatonia , i.e. , ẞ - endorphin - induced muscular rigidity in the rat . This model has been used in experimental procedures ...
Página 5
... psychosis . In 1977 , Gunne and his associates first exam- ined the therapeutic usefulness of naloxone in chronic ... psychotic behavior , should be considered as crucial in determining the ENDORPHINS AND OPIATE ANTAGONISTS IN ...
... psychosis . In 1977 , Gunne and his associates first exam- ined the therapeutic usefulness of naloxone in chronic ... psychotic behavior , should be considered as crucial in determining the ENDORPHINS AND OPIATE ANTAGONISTS IN ...
Página 6
... psychosis is unrelated to opioid dysfunction . In our studies , we observed that behavioral effects such as stereotypy and increased locomotion induced by methylphenidate in rats of different age groups were effectively blocked by ...
... psychosis is unrelated to opioid dysfunction . In our studies , we observed that behavioral effects such as stereotypy and increased locomotion induced by methylphenidate in rats of different age groups were effectively blocked by ...
Página 7
... psychosis . To elicit the antischizophrenic effects , peripherally administered opiate neuropeptides must be capable of traversing the blood - brain barrier . In the rat and mouse , systemic injections of endorphins and enke- phalins ...
... psychosis . To elicit the antischizophrenic effects , peripherally administered opiate neuropeptides must be capable of traversing the blood - brain barrier . In the rat and mouse , systemic injections of endorphins and enke- phalins ...
Contenido
1 | |
4 | |
9 | |
15 | |
CHAPTER 2 | 41 |
CHAPTER 3 | 61 |
Possible Roles of Prostaglandins in Mediating Opioid Actions | 75 |
CHAPTER 5 | 89 |
CHAPTER 13 | 257 |
CHAPTER 14 | 271 |
CHAPTER 15 | 291 |
CHAPTER 16 | 305 |
CHAPTER 18 | 333 |
CHAPTER 19 | 347 |
CHAPTER 21 | 375 |
Enkephalin Naloxone and DESTYR¹yEndorphin | 399 |
CHAPTER 6 | 99 |
CHAPTER 7 | 127 |
CHAPTER 8 | 161 |
CHAPTER 9 | 179 |
CHAPTER 10 | 213 |
CHAPTER 11 | 231 |
CHAPTER 12 | 245 |
CHAPTER 23 | 407 |
CHAPTER 24 | 427 |
CHAPTER 25 | 439 |
CHAPTER 26 | 451 |
CHAPTER 27 | 459 |
Index | 477 |
Otras ediciones - Ver todas
Endorphins and Opiate Antagonists in Psychiatric Research: Clinical Implications Nandkumar S. Shah,Alexander G. Donald Sin vista previa disponible - 2012 |
Términos y frases comunes
Acad acid ACTH action activity administration Akil analgesia analgesic analogs antipsychotic assay B-LPH Barchas behavioral effects Biochem Bloom Brain Res Bunney cerebrospinal fluid chronic clinical concentrations decrease depressed patients dialysate disorders dopamine doses double-blind drugs DTYE Effects of naloxone electrical stimulation endogenous opiates endogenous opioid peptides endorphin levels endorphins enkephalin fraction Goldstein Guillemin hallucinations haloperidol hemodialyses Höllt human hypothalamus immunoreactivity increase infusion inhibition injection Kastin Kline Kosterlitz Lancet ligands lipotropin manic Met-enkephalin methadone morphine naloxone naltrexone narcotic antagonist Natl Nature London neuroleptic neurons Neurosci normal nucleus opiate agonists opiate antagonist opiate peptides opiate receptors opioid peptides pain periaqueductal gray Pert Pharmacol pharmacological placebo plasma potent Proc prolactin Psychiatry psychotic rat brain receptor binding release reported response role schizo schizophrenic schizophrenic patients Science serum Snyder spinal ẞ-endorphin Stereospecific striatum studies suggest symptoms syndrome Terenius tissue treatment vitro Wahlström