Estrogens, Estrogen Receptor and Breast CancerIOS Press, 2000 - 263 páginas Estrogens have been implicated to play a role in the development of breast cancer. The purpose of this book is to provide a comprehensive analysis of experimental, clinical and epidemiological evidence in support of the carcinogenicity of estrogens. |
Contenido
Introduction | 1 |
Estrogen Synthesis and Metabolism | 21 |
viii | 24 |
Estrogen Receptor | 57 |
Estrogen Action | 99 |
Estrogen Receptor Expression in Breast Cancer | 135 |
Estrogens as Breast Cancer Risk Factor | 205 |
Estrogens Estrogen Receptor and Breast Cancer a Unified Model | 243 |
| 249 | |
Términos y frases comunes
4-hydroxytamoxifen Acad Sci USA adducts amino acids analysis anti-estrogens assay Biochem Mol Biol Biol Chem breast cancer cells breast cancer patients breast cancer risk breast carcinoma breast tissue breast tumors cancer cell lines carcinogenesis catechol catechol estrogens cell cycle Chambon coactivator codon complex correlation cyclin D1 cytochrome P450 dimerization DNA binding domain effect Endocrinol 1996 enzyme ER-negative ER-positive estradiol estrogen receptor estrogen-induced estrone exon function growth factor hormone receptor human breast cancer human estrogen receptor hydroxylation increased induced inhibition interaction isoform Katzenellenbogen kinase levels ligand mammary MCF-7 cells metabolites Mol Endocrinol 1997 mRNA mutations Natl Acad Sci Natl Cancer Inst normal breast nuclear receptors nucleotide pathway percent phosphorylation phytoestrogens polymorphism postmenopausal women Proc Natl Acad progesterone receptor proliferation promoter protein region regulation risk of breast role sequence Steroid Biochem Mol steroid hormone steroid receptor studies tamoxifen therapy transcription factor transcriptional activation tumors variant vitro wild type xenoestrogens