Endorphins and Opiate Antagonists in Psychiatric Research: Clinical ImplicationsNandkumar S. Shah, Alexander G. Donald Springer US, 1982 M08 31 - 488 páginas The discovery of new molecules that function in neuronal communication can be viewed as a progression of steps beginning with the identification of the molecular structure, moving to the understanding of the mecha nisms mediating the synaptic action, and to the appraisal of the involve ment of the new molecules in various neuronal mechanisms, and finally reaching the evaluation of this molecule's role in brain function and the consequences that are triggered by its abnormalities. Enkephalins have followed such a pattern, and the present publication expresses the salient points of the last two phases in this succession. Enkephalins were discovered in December 1975; in addition to pain threshold regulation, their participation in other brain functions was soon ascertained. Perhaps, there are multiple recognition sites for multiple molecular forms of endogenous enkephalins; similarly to other transmitter recognition sites, these are coupled with ionic and nucleotide amplifying systems; thus, when activated, they can modify membrane funtion and ionic permeability of membranes. The present publication probes the current status of our knowledge concerning the consequences related to abnormalities in enkephalin storage, release, and synthesis. However, since our basic understanding of enkephalins is incomplete, the views reported should be considered to be in a state of flux. |
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Página 292
... addict patients reported that approximately 65 % of the addicts participating in programs in which a narcotic antagonist was administered discontinued treatment within the first 3 months . Similarly , Resnick and Washton ( 1978 ) ...
... addict patients reported that approximately 65 % of the addicts participating in programs in which a narcotic antagonist was administered discontinued treatment within the first 3 months . Similarly , Resnick and Washton ( 1978 ) ...
Página 293
... addicts . It is a common problem with medications administered for most chronic con- ditions where the medication is given to prevent the progression of the disease rather than to alleviate a symptom that would recur if the med- ication ...
... addicts . It is a common problem with medications administered for most chronic con- ditions where the medication is given to prevent the progression of the disease rather than to alleviate a symptom that would recur if the med- ication ...
Página 302
... addicts in a verified abstinence program : Results of a five - year study , Int . J. Addict . 10 : 211 . Mains , R. E. , and Eipper , B. A. , 1978 , Coordinate synthesis of corticotropins and endorphins by mouse pituitary tumor cells ...
... addicts in a verified abstinence program : Results of a five - year study , Int . J. Addict . 10 : 211 . Mains , R. E. , and Eipper , B. A. , 1978 , Coordinate synthesis of corticotropins and endorphins by mouse pituitary tumor cells ...
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Endorphins and Opiate Antagonists in Psychiatric Research: Clinical Implications Nandkumar S. Shah,Alexander G. Donald Vista previa limitada - 2012 |
Endorphins and Opiate Antagonists in Psychiatric Research: Clinical Implications Nandkumar S. Shah,Alexander G. Donald Sin vista previa disponible - 2012 |
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Acad acid ACTH action activity administration Akil analgesia analgesic analogs antipsychotic assay B-LPH Barchas behavioral effects Biochem Bloom Brain Res Bunney cerebrospinal fluid chronic clinical concentrations decrease depressed patients dialysate disorders dopamine doses double-blind drugs DTYE Effects of naloxone electrical stimulation endogenous opiates endogenous opioid peptides endorphin levels endorphins enkephalin fraction Goldstein Guillemin hallucinations haloperidol hemodialyses Höllt human hypothalamus immunoreactivity increase infusion inhibition injection Kastin Kline Kosterlitz Lancet ligands lipotropin manic Met-enkephalin methadone morphine naloxone naltrexone narcotic antagonist Natl Nature London neuroleptic neurons Neurosci normal nucleus opiate agonists opiate antagonist opiate peptides opiate receptors opioid peptides pain periaqueductal gray Pert Pharmacol pharmacological placebo plasma potent Proc prolactin Psychiatry psychotic rat brain receptor binding release reported response role schizo schizophrenic schizophrenic patients Science serum Snyder spinal ẞ-endorphin Stereospecific striatum studies suggest symptoms syndrome Terenius tissue treatment vitro Wahlström