Endorphins and Opiate Antagonists in Psychiatric Research: Clinical ImplicationsNandkumar S. Shah, Alexander G. Donald Springer US, 1982 M08 31 - 488 páginas The discovery of new molecules that function in neuronal communication can be viewed as a progression of steps beginning with the identification of the molecular structure, moving to the understanding of the mecha nisms mediating the synaptic action, and to the appraisal of the involve ment of the new molecules in various neuronal mechanisms, and finally reaching the evaluation of this molecule's role in brain function and the consequences that are triggered by its abnormalities. Enkephalins have followed such a pattern, and the present publication expresses the salient points of the last two phases in this succession. Enkephalins were discovered in December 1975; in addition to pain threshold regulation, their participation in other brain functions was soon ascertained. Perhaps, there are multiple recognition sites for multiple molecular forms of endogenous enkephalins; similarly to other transmitter recognition sites, these are coupled with ionic and nucleotide amplifying systems; thus, when activated, they can modify membrane funtion and ionic permeability of membranes. The present publication probes the current status of our knowledge concerning the consequences related to abnormalities in enkephalin storage, release, and synthesis. However, since our basic understanding of enkephalins is incomplete, the views reported should be considered to be in a state of flux. |
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Página 258
... depressed patients ( Davis et al . , 1977 ; Terenius et al . , 1977 ) . The differing responses in manic and depressive illness may be due to differences in the dosage , route , and duration of administration of naloxone . Levels of ...
... depressed patients ( Davis et al . , 1977 ; Terenius et al . , 1977 ) . The differing responses in manic and depressive illness may be due to differences in the dosage , route , and duration of administration of naloxone . Levels of ...
Página 367
... depressed group was significantly lower ( p < 0.01 ) than that of 31.9 ± 9.5 ... patients with major depressive disorder reported here may reflect ... depressed patients , need to be explored . However , the blunted prolactin response in ...
... depressed group was significantly lower ( p < 0.01 ) than that of 31.9 ± 9.5 ... patients with major depressive disorder reported here may reflect ... depressed patients , need to be explored . However , the blunted prolactin response in ...
Página 391
... patients . Little experimental data support a specific endorphinergic diathesis in depression . We carried our pilot studies of intravenous and oral methadone ad- ministration in depressed patients as a model for the study of opiate ...
... patients . Little experimental data support a specific endorphinergic diathesis in depression . We carried our pilot studies of intravenous and oral methadone ad- ministration in depressed patients as a model for the study of opiate ...
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Endorphins and Opiate Antagonists in Psychiatric Research: Clinical Implications Nandkumar S. Shah,Alexander G. Donald Vista previa limitada - 2012 |
Endorphins and Opiate Antagonists in Psychiatric Research: Clinical Implications Nandkumar S. Shah,Alexander G. Donald Sin vista previa disponible - 2012 |
Términos y frases comunes
Acad acid ACTH action activity administration Akil analgesia analgesic analogs antipsychotic assay B-LPH Barchas behavioral effects Biochem Bloom Brain Res Bunney cerebrospinal fluid chronic clinical concentrations decrease depressed patients dialysate disorders dopamine doses double-blind drugs DTYE Effects of naloxone electrical stimulation endogenous opiates endogenous opioid peptides endorphin levels endorphins enkephalin fraction Goldstein Guillemin hallucinations haloperidol hemodialyses Höllt human hypothalamus immunoreactivity increase infusion inhibition injection Kastin Kline Kosterlitz Lancet ligands lipotropin manic Met-enkephalin methadone morphine naloxone naltrexone narcotic antagonist Natl Nature London neuroleptic neurons Neurosci normal nucleus opiate agonists opiate antagonist opiate peptides opiate receptors opioid peptides pain periaqueductal gray Pert Pharmacol pharmacological placebo plasma potent Proc prolactin Psychiatry psychotic rat brain receptor binding release reported response role schizo schizophrenic schizophrenic patients Science serum Snyder spinal ẞ-endorphin Stereospecific striatum studies suggest symptoms syndrome Terenius tissue treatment vitro Wahlström