Endorphins and Opiate Antagonists in Psychiatric Research: Clinical ImplicationsNandkumar S. Shah, Alexander G. Donald Springer US, 1982 M08 31 - 488 páginas The discovery of new molecules that function in neuronal communication can be viewed as a progression of steps beginning with the identification of the molecular structure, moving to the understanding of the mecha nisms mediating the synaptic action, and to the appraisal of the involve ment of the new molecules in various neuronal mechanisms, and finally reaching the evaluation of this molecule's role in brain function and the consequences that are triggered by its abnormalities. Enkephalins have followed such a pattern, and the present publication expresses the salient points of the last two phases in this succession. Enkephalins were discovered in December 1975; in addition to pain threshold regulation, their participation in other brain functions was soon ascertained. Perhaps, there are multiple recognition sites for multiple molecular forms of endogenous enkephalins; similarly to other transmitter recognition sites, these are coupled with ionic and nucleotide amplifying systems; thus, when activated, they can modify membrane funtion and ionic permeability of membranes. The present publication probes the current status of our knowledge concerning the consequences related to abnormalities in enkephalin storage, release, and synthesis. However, since our basic understanding of enkephalins is incomplete, the views reported should be considered to be in a state of flux. |
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Página 43
... et al . , 1977 ; Akil et al . , 1978a ; Sar et al . , 1978 ; Neidle et al . , 1979 ) . The phylogenetic distribution of enkephalin supports the evidence that the endogenous peptide is intimately associated with opiate receptors and ...
... et al . , 1977 ; Akil et al . , 1978a ; Sar et al . , 1978 ; Neidle et al . , 1979 ) . The phylogenetic distribution of enkephalin supports the evidence that the endogenous peptide is intimately associated with opiate receptors and ...
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... et al . , 1973 ; Terenius , 1973 ) and their endogenous ligands ( Hughes et al . , 1975 ; Bradbury et al . , 1976 ; Guillemin et al . , 1976 ; Li and Chung , 1976 ) have initiated a new era in research on central mechanisms of pain ...
... et al . , 1973 ; Terenius , 1973 ) and their endogenous ligands ( Hughes et al . , 1975 ; Bradbury et al . , 1976 ; Guillemin et al . , 1976 ; Li and Chung , 1976 ) have initiated a new era in research on central mechanisms of pain ...
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... et al . , 1979 ; Orr and Op- penheimer , 1978 ; Watson et al . , 1978 ) . However , many other studies have reported no change ( Lipinski et al . , 1979 ; see reviews by Emrich et al . , 1979b ; Watson et al . , 1979 ) . In general ...
... et al . , 1979 ; Orr and Op- penheimer , 1978 ; Watson et al . , 1978 ) . However , many other studies have reported no change ( Lipinski et al . , 1979 ; see reviews by Emrich et al . , 1979b ; Watson et al . , 1979 ) . In general ...
Otras ediciones - Ver todas
Endorphins and Opiate Antagonists in Psychiatric Research: Clinical Implications Nandkumar S. Shah,Alexander G. Donald Vista previa limitada - 2012 |
Endorphins and Opiate Antagonists in Psychiatric Research: Clinical Implications Nandkumar S. Shah,Alexander G. Donald Sin vista previa disponible - 2012 |
Términos y frases comunes
Acad acid ACTH action activity administration Akil analgesia analgesic analogs antipsychotic assay B-LPH Barchas behavioral effects Biochem Bloom Brain Res Bunney cerebrospinal fluid chronic clinical concentrations decrease depressed patients dialysate disorders dopamine doses double-blind drugs DTYE Effects of naloxone electrical stimulation endogenous opiates endogenous opioid peptides endorphin levels endorphins enkephalin fraction Goldstein Guillemin hallucinations haloperidol hemodialyses Höllt human hypothalamus immunoreactivity increase infusion inhibition injection Kastin Kline Kosterlitz Lancet ligands lipotropin manic Met-enkephalin methadone morphine naloxone naltrexone narcotic antagonist Natl Nature London neuroleptic neurons Neurosci normal nucleus opiate agonists opiate antagonist opiate peptides opiate receptors opioid peptides pain periaqueductal gray Pert Pharmacol pharmacological placebo plasma potent Proc prolactin Psychiatry psychotic rat brain receptor binding release reported response role schizo schizophrenic schizophrenic patients Science serum Snyder spinal ẞ-endorphin Stereospecific striatum studies suggest symptoms syndrome Terenius tissue treatment vitro Wahlström