Endorphins and Opiate Antagonists in Psychiatric Research: Clinical ImplicationsNandkumar S. Shah, Alexander G. Donald Springer US, 1982 M08 31 - 488 páginas The discovery of new molecules that function in neuronal communication can be viewed as a progression of steps beginning with the identification of the molecular structure, moving to the understanding of the mecha nisms mediating the synaptic action, and to the appraisal of the involve ment of the new molecules in various neuronal mechanisms, and finally reaching the evaluation of this molecule's role in brain function and the consequences that are triggered by its abnormalities. Enkephalins have followed such a pattern, and the present publication expresses the salient points of the last two phases in this succession. Enkephalins were discovered in December 1975; in addition to pain threshold regulation, their participation in other brain functions was soon ascertained. Perhaps, there are multiple recognition sites for multiple molecular forms of endogenous enkephalins; similarly to other transmitter recognition sites, these are coupled with ionic and nucleotide amplifying systems; thus, when activated, they can modify membrane funtion and ionic permeability of membranes. The present publication probes the current status of our knowledge concerning the consequences related to abnormalities in enkephalin storage, release, and synthesis. However, since our basic understanding of enkephalins is incomplete, the views reported should be considered to be in a state of flux. |
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... Hypothalamus Amygdala 2720 ± 196b 3280 122 2580 + 93 2520 ± 85 Midbrain 2420 ± 91 2230 ± 139 Cortex 1850 ± 108 1690 ± 107 Hindbrain 1110 ± 41 1140 ± 100 Experiment 2 Hypothalamus 2690 + 30 3080 ± 122d Striatum 2500 ± 205 2730 ± 175 ...
... Hypothalamus Amygdala 2720 ± 196b 3280 122 2580 + 93 2520 ± 85 Midbrain 2420 ± 91 2230 ± 139 Cortex 1850 ± 108 1690 ± 107 Hindbrain 1110 ± 41 1140 ± 100 Experiment 2 Hypothalamus 2690 + 30 3080 ± 122d Striatum 2500 ± 205 2730 ± 175 ...
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... Hypothalamus 2440 + 949 2430 ± 93 Amygdala 2190 ± 87 2160 + 86 Cortex 1470 ± 62 1400 ± 103 Experiment 2 ( 10 sec ) Hypothalamus 2440153 2210 ± 25 Amygdala ... hypothalamus . Since hypothalamic ß - endorphin is 142 VIKTOR HAVLICEK ET AL .
... Hypothalamus 2440 + 949 2430 ± 93 Amygdala 2190 ± 87 2160 + 86 Cortex 1470 ± 62 1400 ± 103 Experiment 2 ( 10 sec ) Hypothalamus 2440153 2210 ± 25 Amygdala ... hypothalamus . Since hypothalamic ß - endorphin is 142 VIKTOR HAVLICEK ET AL .
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... hypothalamic slices ( Lemon et al . , 1980 ) . The hypothalamus was dissected from decapitated male Spra- gue - Dawley rats ( 200-350 g ) . Tissue from two rats ( 120-140 mg ) was sliced with a tissue chopper and added to a jacketed ...
... hypothalamic slices ( Lemon et al . , 1980 ) . The hypothalamus was dissected from decapitated male Spra- gue - Dawley rats ( 200-350 g ) . Tissue from two rats ( 120-140 mg ) was sliced with a tissue chopper and added to a jacketed ...
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Endorphins and Opiate Antagonists in Psychiatric Research: Clinical Implications Nandkumar S. Shah,Alexander G. Donald Vista previa limitada - 2012 |
Endorphins and Opiate Antagonists in Psychiatric Research: Clinical Implications Nandkumar S. Shah,Alexander G. Donald Sin vista previa disponible - 2012 |
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Acad acid ACTH action activity administration Akil analgesia analgesic analogs antipsychotic assay B-LPH Barchas behavioral effects Biochem Bloom Brain Res Bunney cerebrospinal fluid chronic clinical concentrations decrease depressed patients dialysate disorders dopamine doses double-blind drugs DTYE Effects of naloxone electrical stimulation endogenous opiates endogenous opioid peptides endorphin levels endorphins enkephalin fraction Goldstein Guillemin hallucinations haloperidol hemodialyses Höllt human hypothalamus immunoreactivity increase infusion inhibition injection Kastin Kline Kosterlitz Lancet ligands lipotropin manic Met-enkephalin methadone morphine naloxone naltrexone narcotic antagonist Natl Nature London neuroleptic neurons Neurosci normal nucleus opiate agonists opiate antagonist opiate peptides opiate receptors opioid peptides pain periaqueductal gray Pert Pharmacol pharmacological placebo plasma potent Proc prolactin Psychiatry psychotic rat brain receptor binding release reported response role schizo schizophrenic schizophrenic patients Science serum Snyder spinal ẞ-endorphin Stereospecific striatum studies suggest symptoms syndrome Terenius tissue treatment vitro Wahlström